https://www.travera.com/home daily 1.0 2024-08-28 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/45d1e655-3a61-4628-b6a9-2e3b560ee3ea/GettyImages-1389960623.jpg https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/1657830308735-CDN3UDIAUMR614M0AEYT/GettyImages-1026367516.jpg Rapid Therapy Selection™ for Cancer Patients & Caregivers - Your Expanded Cancer Treatment Plan While the FDA has approved many drugs to treat specific cancers, every cancer patient’s cells are unique. Not all approved drugs work for all people at every cancer stage. Your physician, assisted by Travera’s experts, will define the panel of cancer drugs and drug combinations to be tested, based on your cancer type and stage. You can have a panel of up to 20 FDA-approved drugs tested per test order to determine which drugs or drug combinations have the potential to disrupt the growth of your cancer cells. https://www.travera.com/technology daily 0.75 2024-02-27 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/2416b3c9-49f0-4503-8cda-f2fa4ce7bf80/GettyImages-1357522266.jpg Rapid Therapy Guidance™ Technology - A Clear Path to Personalized Cancer Therapy Our Rapid Therapy Selection™ test overcomes previous biological and clinical barriers to personalized cancer therapy. Past efforts have focused on measuring cell death, a process that can take over a week and has shown no sustainable clinical success. Since a cell’s weight change ex vivo happens in hours, we eliminate the difficulty of having to distinguish between natural cell death and cell death induced by a cancer drug. Preliminary studies have shown that Travera’s Rapid Therapy Selection™ test applies to many different cancer drugs with different mechanisms of action across 90% of cancers. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/28203255-ee8b-4be5-89c1-66766ad7f81f/TRAVERA-tech.jpg Rapid Therapy Guidance™ Technology - Make it stand out The Suspended Microchannel Resonator https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/d2d91621-590b-42ca-af02-cc329c86fa4d/TRAVERA-measurements3.png Rapid Therapy Guidance™ Technology - Make it stand out Our Clinical Platform And Workflow https://www.travera.com/healthcare-professionals daily 0.75 2024-07-22 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/9f42bfcf-8fb2-4dc6-9f2f-4fcd6b6b2226/male-patient_G_1134458137.jpg https://www.travera.com/how-it-works daily 0.75 2023-07-06 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/1650944778509-41FD7MXG5CV10B07S7Q8/unsplash-image-BxXgTQEw1M4.jpg Rapid Therapy Guidance™ - How it works for Patients & Caregivers - Patients & Caregivers How it works In an unprecedented two-day turnaround time, Travera gives you the information you need to take control of your cancer care. The process starts with a test order and biopsy and ends with a detailed report to help your physician define your next treatment. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/8e14538e-e3d1-459d-ab83-b95e1c81c7d3/80488087_s.jpg Rapid Therapy Guidance™ - How it works for Patients & Caregivers https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/1650945136614-UQF4VBKZ1NP2EHMZHIQ4/unsplash-image-BfP3E4rpxl8.jpg Rapid Therapy Guidance™ - How it works for Patients & Caregivers https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/7c0930ba-bd8f-4811-bbb9-20b3bfc76f69/many-cancer-patients-skimp-on-treatment-due-to-cost.jpeg Rapid Therapy Guidance™ - How it works for Patients & Caregivers https://www.travera.com/clinical-evidence daily 0.75 2024-08-28 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/676955dc-c4d0-4d72-9f42-d7b89be7572a/jco_po-rgb.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/dead1e06-ce39-4320-9adb-54249e084ec2/Screenshot+2024-08-28+at+12.35.57%E2%80%AFPM.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/d8abdc4b-5975-4264-af00-5f59437e3409/nature.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/cf5be846-b929-4ee0-b8b8-841cb273af7b/Screenshot+2024-08-28+at+12.37.44%E2%80%AFPM.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/eeaa9a21-3753-495e-8c56-795cfa094b4b/1.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/4821421b-b9dc-4159-949a-30d6349716c1/4.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/dacdefdc-a047-4f32-b527-e3ff3374c86a/7.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/98291577-553a-43d2-b3b0-159d9484446e/2.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/ed8e1255-f4b9-4aae-9072-5b62da25f963/3.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/35f59d69-3b2e-4e1d-bd33-2a5c95a0cea8/6.png https://www.travera.com/support daily 0.75 2023-02-08 https://www.travera.com/earlyaccess daily 0.75 2024-07-22 https://www.travera.com/smr daily 0.75 2023-07-06 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/210521d7-eae0-428a-b0ce-134846de969e/TRAVERA-chip.jpg The Suspended Microchannel Resonator - Make it stand out The SMR MEMS chip on a finger https://www.travera.com/company daily 0.75 2026-03-27 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/0b017ee3-751a-4313-8ba6-cacea7a1ceea/TRAVERA-measurements3.jpg Company Information - About Travera Travera assists oncologists in selecting treatments for their patients with our revolutionary cancer therapy guidance test that predicts which cancer drugs are most likely to be effective for each cancer patient. Using a disruptive single-cell measurement technology invented at MIT that measures the ex vivo growth response of live tumor cells to candidate drugs, Travera has overcome the problems that have prevented the many previous generations of therapy guidance tests from being effective in clinical practice. Travera’s 2-day Rapid Therapy Guidance™ test enables patients who are running out of therapeutic options to discover additional options and continue their battle against cancer. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/2e08119d-fc0a-4c95-b7a1-cb06eda88bec/GettyImages-1389960623.jpg Company Information - Our Commitment When patients feel out of options, they lose the strength and will to continue the battle against their cancer. Travera is committed to improving both patient experience and outcomes. We offer physicians an effective way to personalize their patients’ cancer treatment and potentially increase their therapeutic options in an unprecedented two-day turnaround. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/3f302a14-7f5e-4d5b-a208-cabe5f3dd2c0/investors.png Company Information - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.travera.com/results daily 0.75 2023-07-06 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/1a28aaab-23b9-4aa4-b8c1-11c52e0fee65/Travera-Test_Example.png https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/7ad26cba-39ff-4afd-9aff-3de3f061ab1d/Travera_report_v3.1_DRAFT.jpg Rapid Therapy Guidance™ test results - Make it stand out Summary of the results Each drug is scored between 0 and 100, and the list of drugs is sorted, with the highest scoring (likely effective) drugs at the top. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/5c21ccdf-e702-4fa6-82a2-af0c08d534ca/Travera_report_v3.1_DRAFT2.jpg Rapid Therapy Guidance™ test results - Make it stand out Detailed results The details behind the score for each drug: a graph and a table of the mass change measurement data and the confidence (p-value) scores. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/941cd653-b8ac-4236-a80c-7fd0bb89dc18/Travera_report_v3.1_DRAFT3.jpg Rapid Therapy Guidance™ test results - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/cf9d048b-a9b4-4115-8676-5b586ea9026a/Travera_report_v3.1_DRAFT4.jpg Rapid Therapy Guidance™ test results - Make it stand out Results Explanation A concise explanation of how the scores are computed from the measurement data shown on the previous pages. https://www.travera.com/drugs daily 0.75 2023-07-06 https://www.travera.com/cancer-selection daily 0.75 2024-08-28 https://www.travera.com/how-it-works-hcp daily 0.75 2024-07-22 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/3a342053-503f-4bd3-846e-248fadc730de/esveikata-scaled.jpg Rapid Therapy Guidance™ - How it works for Oncologists - Healthcare Professionals How it works In an unprecedented two-day turnaround time, Travera gives you the information you need to take control of your patient’s cancer care. The process starts with a test order and sample collection and ends with a detailed report to help you define your patient’s next treatment. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/8e14538e-e3d1-459d-ab83-b95e1c81c7d3/80488087_s.jpg Rapid Therapy Guidance™ - How it works for Oncologists https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/1651543231898-5Q6NKMQUAAQ6D3HYGBSX/unsplash-image-BxXgTQEw1M4.jpg Rapid Therapy Guidance™ - How it works for Oncologists https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/7c0930ba-bd8f-4811-bbb9-20b3bfc76f69/many-cancer-patients-skimp-on-treatment-due-to-cost.jpeg Rapid Therapy Guidance™ - How it works for Oncologists https://www.travera.com/clinical-platform-and-workflow daily 0.75 2022-06-20 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/cd1353fb-79a8-4320-af25-1f45856f7d7d/TRAVERA-purification2.png Clinical Platform and Workflow - 1 Purifying The Cells As soon as we receive the biopsy sample, we begin a purification process to isolate the cancer cells for testing. For blood cancers, we use a positive selection method that identifies and isolates the cancer cells based on known proteins on the cancer cell membranes. For solid tumors, we dissociate the tissue into a single cell suspension and use a negative selection method that destroys the non-cancerous cells, resulting in a high concentration of cancer cells suitable for testing. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/416f28dc-ca63-47db-abe9-b6f7cfc38bb8/TRAVERA-purification.png Clinical Platform and Workflow - 2 Dosing And Incubating The Cells A portion of the purified cells is used for assessing drug effectiveness and another portion is used as controls. Each sample is divided into multiple wells, with a single drug or drug combination added to the test wells and no drug added to the control wells. We incubate the samples for approximately 15 hours. The cancer cells that receive cytotoxic drugs (such as chemotherapies and targeted inhibitors) are incubated in minimal media only. For immunotherapies (antibodies and checkpoint inhibitors) we include the immune system components (NK cells, T cells, and complementary proteins) required to enable the anti-cancer activity of the drug. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/0b017ee3-751a-4313-8ba6-cacea7a1ceea/TRAVERA-measurements3.jpg Clinical Platform and Workflow - 3 Measuring Mass Distribution Immediately following the incubation period, we measure the mass distributions of the cells from each well using our proprietary Suspended Microchannel Resonator (SMR). Since the cell purification process leaves impurities that can interfere with our mass distribution measurements, we use an AI-based image classification system to identify and remove impurities before doing our calculations. We produce a brightfield image of each particle entering the SMR, link the image to the mass measurement, and use a manually curated training set of approximately 20,000 images of healthy cells, dead cells, debris, and clusters to automatically classify each particle. This enables us to remove the debris and clusters from the calculation of the mass distributions. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/256300e9-eff1-4541-9c4e-5b6dd99424ad/TRAVERA-calculations.png Clinical Platform and Workflow - 4 Calculating Drug Response Once we have measured the masses of the cells in all the wells, we compare the difference in the mass distributions of the cells exposed to drugs to the cells in the control group and calculate whether the measurements are significantly different. We use the p-value as the standard measure of statistical confidence. We convert p-values to a score of 0-100, where scores less than 50 correspond to “no drug response” from resistant cells, and scores greater than or equal to 50 correspond to “positive drug response” from sensitive cells. https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/3a342053-503f-4bd3-846e-248fadc730de/esveikata-scaled.jpg Clinical Platform and Workflow - 5 Reporting Results We generate a report that includes drug sensitivity information along with a variety of quality control and other measurements we make during the process. We submit this report to the ordering physician the day after we receive the sample. https://www.travera.com/resources daily 0.75 2023-04-18 https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/ceffd70c-f38a-4bb4-9882-fb281fe38165/Travera+Clinical+Evidence+Document.png Rapid Therapy Guidance™ Resources - Make it stand out Download Summary https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/d6cf926f-3829-43e8-b5cc-11adad65322a/Travera+Clinical+Evidence+Dossier.png Rapid Therapy Guidance™ Resources - Make it stand out Download Dossier https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/29b89ca2-b2dd-4c95-9bae-0473f93d5c36/Travera+Literature+References.png Rapid Therapy Guidance™ Resources - Make it stand out Download References https://images.squarespace-cdn.com/content/v1/61e5fc60455d4178d305aedb/ef4a80c0-bf90-4fce-974f-afc8239ed3ef/Travera+Clinical+Study+Summary.png Rapid Therapy Guidance™ Resources - Make it stand out Review 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